The 49ers suffer their latest RB injury against the Chicago Bears

The San Francisco 49ers are dealing with all sorts of injury concerns in their offensive backfield.

Star running back Christian McCaffrey and fellow running back Jordan Mason were each placed on IR this week. McCaffrey is dealing with a PCL injury while Mason has an ankle injury.

That meant the 49ers had to rely on rookie running back Isaac Guerendo for Sunday’s game against the Chicago Bears and for the rest of the regular season.

Guerendo earned his first career win against the Bears and performed admirably on Sunday. Guerendo had 15 carries for 78 rushing yards and rushing scores of 1 and 4 yards. The Louisville product also caught two passes for 50 yards.

With his 128 scrimmage yards against the Bears, Guerendo joins a distinguished list of 49ers with over 100 scrimmage yards and at least two touchdowns in their first career start.

However, Guerendo had to leave the 49ers’ game against Chicago with a reported foot injury. Guerendo’s return was considered questionable.

#CHIvsSF @DignityHealth Injury update: Isaac Guerendo (foot) is questionable to return.

— San Francisco 49ers (@49ers) December 9, 2024

Fourth-year pro Patrick Taylor serves as the 49ers’ backup running back. After Guerendo’s retirement due to injury, Taylor immediately reached the end zone with a 3-yard rushing score, extending the 49ers’ commanding lead over the Bears to 38-13.

However, given the health of San Francisco’s backfield, this is an important situation to watch with Guerendo.